SkinCare Physicians Doctors

Dupixent: A New Treatment Option for Bullous Pemphigoid, a Rare Skin Disease

Published on Oct 2nd, 2025 by Jeffrey Sobell, MD

Closeup of blisters from bullous pemphigoid, a rare skin conditionBullous pemphigoid (BP) is a rare skin disease that mostly affects older adults over 60. It happens when the immune system mistakenly attacks a layer of the skin, leading to painful blisters, redness, and intense itching. While the cause is not fully understood, we now have Dupixent to treat the BP disease.

Limitations of current BP treatments

Until now, the main treatment for BP has been high-dose steroids, sometimes combined with other immune-suppressing drugs. While these medicines can help calm the disease, they often cause serious side effects like infections, weight gain, bone loss, and diabetes. Many patients also see their symptoms return once the medicine is reduced.

Dupixent: A targeted approach to BP

In June 2025, the FDA approved Dupixent (dupilumab) as the first targeted treatment for BP. Already established as a cornerstone therapy for atopic dermatitis and recently approved for chronic spontaneous urticaria (CSU), Dupixent takes a more precise approach than traditional immunosuppressants. Instead of broadly shutting down the immune system, the biologic blocks two specific protein signals, called Interleukin 4 (IL-4) and Interleukin (IL-13), that are key drivers of inflammation and blistering in BP.

In a large clinical trial, people taking Dupixent had much better outcomes than those on placebo:

  • About 1 in 5 patients reached full disease control, meaning no new blisters and healed skin, while using less or no steroids.
  • Nearly 40% had major improvement in their symptoms
  • Many reported relief from severe itching.

The most common side effect was mild cold-like symptoms.

A new era of hope for patients

For the first time, people with BP have a treatment designed specifically for their disease. This new approval brings real hope for better control, fewer side effects, and an improved quality of life.  If you or a loved one is living with BP, find out what solutions are now possible by consulting with our skilled providers at SkinCare Physicians.

Leave a Reply

Fields marked with * are required.

Back to top

Our Promise

Our team of renowned physicians and experienced support staff is committed to excellence in medical skin care and cosmetic procedures with a patient-centered focus for women and men in the greater Boston area and beyond.

Request a Consultation

Contact Us

The form below should not be used by patients to communicate clinical questions to SkinCare Physicians. It is not a patient portal. If your message is of an urgent, clinical or confidential nature, please call us instead at 1-617-383-8201.

Fields marked * are required


Terms of Use*
By checking the box on the contact form, you agree to the Terms of Use listed here: Communications through our website or via email are not encrypted and are not necessarily secure. Use of the internet or email is for your convenience only, and by using them, you assume the risk of unauthorized use. By checking this box you hereby agree to hold SkinCare Physicians, its doctors and affiliates, harmless from any hacking or any other unauthorized use of your personal information by outside parties.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Physician society logos

SkinCare Physicians®

1244 Boylston Street (Route 9)
Chestnut Hill, Massachusetts 02467

Learn more about your rights and protections related to the No Surprises Act (HR133).

The dermatologists and other medical professionals at SkinCare Physicians specialize in a wide range of dermatology treatments and services, including laser hair removal, laser skin treatment, hair transplant, eyelid surgery, body contouring, psoriasis, skin cancer, BOTOX® Cosmetic, fillers, and Thermage®. From their offices in Chestnut Hill, they serve Boston, Brookline, Cambridge, Newton and Wellesley.

Keep in mind that each patient is unique and your results may vary.



SkinCare Physicians®
1244 Boylston Street (Route 9)
Chestnut Hill, Massachusetts 02467

Phone: (617) 731-1600 Fax: (617) 731-1601

Learn more about your rights and protections related to the No Surprises Act (HR133).

Keep in mind that each patient is unique and your results may vary.

The dermatologists and other medical professionals at SkinCare Physicians specialize in a wide range of dermatology treatments and services, including laser hair removal, laser skin treatment, hair transplant, eyelid surgery, body contouring, psoriasis, skin cancer, BOTOX® Cosmetic, fillers, and Thermage®. From their offices in Chestnut Hill, they serve Boston, Brookline, Cambridge, Newton and Wellesley.