SkinCare Physicians

What you need to know about newly approved Zoryve and Vtama psoriasis creams

Published on Aug 17th, 2022 by Jeffrey Sobell, MD

Dr. Jeffrey Sobell with samples of Zoryve and Vtama, non-steroidal creams for psoriasis.August is Psoriasis Awareness Month, also known as Psoriasis Action Month. The recognition of this event is especially sweet this year as two novel non-steroidal topical medications for psoriasis, Zoryve® and Vtama®, have just received FDA approval, which had not happened in over twenty years! Dr. Jeffrey Sobell, a Boston-based renowned expert in the field of psoriasis, shares the basics on these two novel creams.

What’s exciting about Zoryve® and Vtama®

Both creams appear much more effective than the 2 long-standing steroid-free psoriasis creams, calcipotriene (Dovonex) and tazarotene (Tazorac). It is also exciting that thinning of the skin, a potential and concerning side effect of commonly used topical corticosteroids, is not seen with either cream. Consequently, there is no limit on the duration of use of these products.

Zoryve® for plaque and inverse psoriasis

Zoryve® (roflumilast cream 0.3%), approved for plaque and inverse* psoriasis in ages 12 years and older, targets inflammation by inhibiting PDE-4**. In two large pivotal studies, roughly 40% of subjects were clear or almost clear of psoriasis after 8 weeks of once daily application. Even higher success rates were seen when used for psoriasis in sensitive skin folds, namely under the arms, below the breasts or in the groin folds. In addition, most subjects have clinically meaningful improvements in itch. Zoryve® is well tolerated with a low rate of application site pain or reaction.

Vtama® for plaque psoriasis

Vtama® (tapinarof cream 1%) is a novel small molecule TAMA***. Like Zoryve®, once daily application of Vtama® demonstrated reproducible and exciting results with 40% achieving clear or almost clear skin by week 12. Even more promising, remission is possible, with improvements lasting months after discontinuing therapy. The cream was well tolerated, with folliculitis and contact dermatitis occurring in a minority of subjects. Vtama® is indicated for adults with plaque psoriasis.

Plaque psoriasis on elbow and inverse psoriasis under arm

To help put this into context, we suggest coming in for a consultation with one of our skilled and trusted providers at SkinCare Physicians to discuss whether these new and exciting psoriasis treatment creams might be the right answer for you.

* Inverse psoriasis appears in skin folds where skin rubs against itself
** PDE-4: Phosphodiesterase-4
*** TAMA: Therapeutic aryl hydrocarbon receptor-modulating agent
(1) Photo courtesy of Medical News Today


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SkinCare Physicians®
1244 Boylston Street (Route 9)
Chestnut Hill, Massachusetts 02467

Phone: (617) 731-1600 Fax: (617) 731-1601

Learn more about your rights and protections related to the No Surprises Act (HR133).

Medical Website Design & Marketing by Etna Interactive

The dermatologists and other medical professionals at SkinCare Physicians specialize in a wide range of dermatology treatments and services, including laser hair removal, laser skin treatment, hair transplant, eyelid surgery, body contouring, psoriasis, skin cancer, BOTOX® Cosmetic, fillers, and Thermage®. From their offices in Chestnut Hill, they serve Boston, Brookline, Cambridge, Newton and Wellesley.