SkinCare Physicians

Sotyktu®, a breakthrough pill therapy for psoriasis now available

Published on Dec 15th, 2022 by Jeffrey Sobell, MD

Dr. Sobell holding a box of the breakthrough pill treatment for psoriasis, SotyktuThose suffering from psoriasis have a new reason to rejoice! The FDA has recently approved a novel medication called Sotyktu® (deucravacitinib). Unlike biologics, which are administered by injection, Sotyktu® is a pill taken once a day. Astonishingly, there hasn’t been a new oral medication available for psoriasis in almost 10 years!

Sotyktu® is the first therapy in a new category of medications called selective TYK-2 inhibitors. The excitement surrounding this pill is how precisely it targets the excessive inflammation associated with psoriasis. It is believed that this explains the high clinical benefit and favorable safety profile observed in patients while on treatment.

Sotyktu®’s approval was based on results from two large clinical studies. After 16 weeks of treatment, nearly 6/10 subjects in study-1 had more than 75% improvement in their psoriasis (PASI 75*). Notably, this increased to 7/10 subjects by week 24. Many subjects experienced even greater improvement, with 1/5 achieving totally clear skin by week 52!

Side effects seen in more than 1% of subjects included mild upper respiratory tract infections, acne, oral cold sores, mouth ulcers and an increase in the creatinine phosphokinase (CPK**) protein found in muscle tissue. A screening test for tuberculosis exposure is mandatory before starting treatment, a requirement commonly seen with other available systemic medications for psoriasis.

Although Sotyktu® was just recently approved, the dermatologists at SkinCare Physicians who were principally involved in studying the drug already have over 3 years of experience treating patients thus far. The treatment of psoriasis has progressed exponentially just in the last decade, with researchers at SkinCare Physicians leading the way. If you suffer from this life-altering skin disease, find out what solutions are now possible by consulting with the skilled physicians at our Psoriasis Treatment Center.

* PASI 75: 75% improvement in psoriasis from baseline in Psoriasis Area and Severity Index
** CPK: Creatinine phosphokinase


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    Chestnut Hill, MA (617) 731-1600

    SkinCare Physicians®
    1244 Boylston Street (Route 9)
    Chestnut Hill, Massachusetts 02467

    Phone: (617) 731-1600 Fax: (617) 731-1601


    Learn more about your rights and protections related to the No Surprises Act (HR133).

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    SkinCare Physicians®
    1244 Boylston Street (Route 9)
    Chestnut Hill, Massachusetts 02467

    Phone: (617) 731-1600 Fax: (617) 731-1601

    Learn more about your rights and protections related to the No Surprises Act (HR133).

    Medical Website Design & Marketing by Etna Interactive

    The dermatologists and other medical professionals at SkinCare Physicians specialize in a wide range of dermatology treatments and services, including laser hair removal, laser skin treatment, hair transplant, eyelid surgery, body contouring, psoriasis, skin cancer, BOTOX® Cosmetic, fillers, and Thermage®. From their offices in Chestnut Hill, they serve Boston, Brookline, Cambridge, Newton and Wellesley.